2W3L: Crystal Structure Of Chimaeric Bcl2-xl And Phenyl Tetrahydroisoquinoline Amide Complex

Citation:
Abstract
Anti-apoptotic Bcl-2 protects cells from apoptosis by binding to pro-apoptotic members of the Bcl-2 family thereby playing a role in tumour survival in response to chemo- or radiation therapy. We describe a series of phenyl pyrazoles that have high affinity for Bcl-2 and rationalise the observed SAR by means of an X-ray crystal structure.
PDB ID: 2W3LDownload
MMDB ID: 68351
PDB Deposition Date: 2008/11/13
Updated in MMDB: 2008/12
Experimental Method:
x-ray diffraction
Resolution: 2.1  Å
Source Organism:
Similar Structures:
Biological Unit for 2W3L: monomeric; determined by author and by software (PQS)
Molecular Components in 2W3L
Label Count Molecule
Protein (1 molecule)
1
Apoptosis Regulator Bcl-2(Gene symbol: BCL2)
Molecule annotation
Chemical (1 molecule)
1
1
* Click molecule labels to explore molecular sequence information.

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