National Center for
2VWV: Ephb4 Kinase Domain Inhibitor Complex
Inhibitors of the tyrosine kinase EphB4. Part 1: Structure-based design and optimization of a series of 2,4-bis-anilinopyrimidines
Bioorg. Med. Chem. Lett. (2008) 18 p.2776-2780
A series of bis-anilinopyrimidines have been identified as potent inhibitors of the tyrosine kinase EphB4. Structural information from two alternative series identified from screening efforts was combined to identify the initial leads.