National Center for
2VVV: Aminopyrrolidine-related Triazole Factor Xa Inhibitor
Eur J Med Chem (2009) 44 p.2787-2795
Starting from a hit identified by focused screening, 3-aminopyrrolidine factor Xa inhibitors were designed. The binding mode as determined by X-ray structural analysis as well as the pharmacokinetic behaviour of selected compounds is discussed.