2VSG: A Structural Motif In The Variant Surface Glycoproteins Of Trypanosoma Brucei

Citation:
Abstract
The variable domain of the trypanosome variant surface glycoprotein (VSG) ILTat 1.24 has been shown by X-ray crystallography to resemble closely the structures of VSG MITat 1.2, despite their low sequence similarity. Specific structural features of these VSGs, including substitution of carbohydrate for an alpha-helix, can be found in other VSG sequences. Thus antigenic variation in trypanosomes is accomplished by sequence variation, not gross structural alteration; the extensive sequence differences among VSGs may be required for another reason, such as the avoidance of recognition by helper T cells. Additionally, VSG sequences are found to define families, within a VSG superfamily, which have evolved in the trypanosome genome.
PDB ID: 2VSGDownload
MMDB ID: 12284
PDB Deposition Date: 1998/11/19
Updated in MMDB: 2017/10
Experimental Method:
x-ray diffraction
Resolution: 2.7  Å
Source Organism:
Similar Structures:
Biological Unit for 2VSG: dimeric; determined by author and by software (PISA)
Molecular Components in 2VSG
Label Count Molecule
Proteins (2 molecules)
2
Variant Surface Glycoprotein Iltat 1.24
Molecule annotation
* Click molecule labels to explore molecular sequence information.

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