2UUS: Crystal Structure Of The Rat Fgf1-sucrose Octasulfate (sos) Complex

Citation:
Abstract
Fibroblast growth factors (FGFs) constitute a family of at least 23 structurally related heparin-binding proteins that are involved in regulation of cell growth, survival, differentiation and migration. Sucrose octasulfate (SOS), a chemical analogue of heparin, has been demonstrated to activate FGF signalling pathways. The structure of rat FGF1 crystallized in the presence of SOS has been determined at 2.2 A resolution. SOS-mediated dimerization of FGF1 was observed, which was further supported by gel-filtration experiments. The major contributors to the sulfate-binding sites in rat FGF1 are Lys113, Lys118, Arg122 and Lys128. An arginine at position 116 is a consensus residue in mammalian FGF molecules; however, it is a serine in rat FGF1. This difference may be important for SOS-mediated FGF1 dimerization in rat.
PDB ID: 2UUSDownload
MMDB ID: 64391
PDB Deposition Date: 2007/3/7
Updated in MMDB: 2008/06
Experimental Method:
x-ray diffraction
Resolution: 2.2  Å
Source Organism:
Similar Structures:
Biological Unit for 2UUS: monomeric; determined by author and by software (PQS)
Molecular Components in 2UUS
Label Count Molecule
Protein (1 molecule)
1
Heparin-binding Growth Factor 1(Gene symbol: Fgf1)
Molecule annotation
Chemical (1 molecule)
1
1
* Click molecule labels to explore molecular sequence information.

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