2REB: The Structure Of The E. Coli Reca Protein Monomer And Polymer

The crystal structure of the recA protein from Escherichia coli at 2.3-A resolution reveals a major domain that binds ADP and probably single- and double-stranded DNA. Two smaller subdomains at the N and C termini protrude from the protein and respectively stabilize a 6(1) helical polymer of protein subunits and interpolymer bundles. This polymer structure closely resembles that of recA/DNA filaments determined by electron microscopy. Mutations in recA protein that enhance coprotease, DNA-binding and/or strand-exchange activity can be explained if the interpolymer interactions in the crystal reflect a regulatory mechanism in vivo.
PDB ID: 2REBDownload
MMDB ID: 58193
PDB Deposition Date: 1992/3/6
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
Similar Structures:
Biological Unit for 2REB: monomeric; determined by author
Molecular Components in 2REB
Label Count Molecule
Protein (1 molecule)
REC a(Gene symbol: recA)
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB