2QU4: Model For Bacterial Parm Filament

Citation:
Abstract
Bacterial ParM is a homolog of eukaryotic actin and is involved in moving plasmids so that they segregate properly during cell division. Using cryo-EM and three-dimensional reconstruction, we show that ParM filaments have a different structure from F-actin, with very different subunit-subunit interfaces. These interfaces result in the helical handedness of the ParM filament being opposite to that of F-actin. Like F-actin, ParM filaments have a variable twist, and we show that this involves domain-domain rotations within the ParM subunit. The present results yield new insights into polymorphisms within F-actin, as well as the evolution of polymer families.
PDB ID: 2QU4Download
MMDB ID: 59547
PDB Deposition Date: 2007/8/3
Updated in MMDB: 2012/11
Experimental Method:
electron microscopy
Resolution: 16  Å
Source Organism:
Similar Structures:
Biological Unit for 2QU4: decameric
Molecular Components in 2QU4
Label Count Molecule
Proteins (10 molecules)
10
Plasmid Segregation Protein Parm(Gene symbol: stbA)
Molecule annotation
* Click molecule labels to explore molecular sequence information.

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