2QR7: 2.0a X-Ray Structure Of C-Terminal Kinase Domain Of P90 Ribosomal S6 Kinase 2: Se-Met Derivative

The X-ray structure at 2.0-A resolution of the p90 ribosomal S6 kinase 2 C-terminal kinase domain revealed a C-terminal autoinhibitory alphaL-helix that was embedded in the kinase scaffold and determines the inactive kinase conformation. We suggest a mechanism of activation through displacement of the alphaL-helix and rearrangement of the conserved residue Glu500, as well as the reorganization of the T-loop into the active conformation.
PDB ID: 2QR7Download
MMDB ID: 61196
PDB Deposition Date: 2007/7/27
Updated in MMDB: 2007/12
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 2QR7: monomeric; determined by author and by software (PISA)
Molecular Components in 2QR7
Label Count Molecule
Protein (1 molecule)
Ribosomal Protein S6 Kinase Alpha-3(Gene symbol: Rps6ka3)
Molecule annotation
Chemical (1 molecule)
* Click molecule labels to explore molecular sequence information.

Citing MMDB