National Center for
2QK5: Structure Of Bace1 Bound To Sch626485
Bioorg. Med. Chem. Lett. (2008) 18 p.414-417
Based on lead compound 1 identified from the patent literature, we developed novel patentable BACE-1 inhibitors by introducing a cyclic amine scaffold. Extensive SAR studies on both pyrrolidines and piperidines ultimately led to inhibitor 2f, one of the most potent inhibitors synthesized to date.