2QCX: Crystal Structure Of Bacillus Subtilis Tena Y112f Mutant Complexed With Formyl Aminomethyl Pyrimidine

TenA catalyzes the hydrolysis of 4-amino-5-aminomethyl-2-methylpyrimidine and participates in the salvage of base-degraded thiamin. Here, we describe mutagenesis of the active site of TenA guided by structures of the enzyme complexed to a substrate analog and to the product. Catalytic roles for each of the active site residues are identified and a mechanism for the reaction is described.
PDB ID: 2QCXDownload
MMDB ID: 60211
PDB Deposition Date: 2007/6/19
Updated in MMDB: 2012/11
Experimental Method:
x-ray diffraction
Resolution: 2.2  Å
Source Organism:
Similar Structures:
Biological Unit for 2QCX: tetrameric; determined by author and by software (PISA)
Molecular Components in 2QCX
Label Count Molecule
Proteins (4 molecules)
Transcriptional Activator Tena(Gene symbol: tenA)
Molecule annotation
Chemicals (4 molecules)
* Click molecule labels to explore molecular sequence information.

Citing MMDB