2Q2Y: Crystal Structure Of Ksp In Complex With Inhibitor 1

Citation:
Abstract
Inspired by previous efforts in the pyrazolobenzoxazine class of KSP inhibitors, the design and synthesis of 1,4-diaryl-4,5-dihydropyrazole inhibitors of KSP are described. Crystallographic evidence of binding mode and in vivo potency data is also highlighted.
PDB ID: 2Q2YDownload
MMDB ID: 59374
PDB Deposition Date: 2007/5/29
Updated in MMDB: 2011/10
Experimental Method:
x-ray diffraction
Resolution: 2.5  Å
Source Organism:
Similar Structures:
Biological Unit for 2Q2Y: monomeric; determined by author
Molecular Components in 2Q2Y
Label Count Molecule
Protein (1 molecule)
1
Kinesin-like Protein Kif11(Gene symbol: KIF11)
Molecule annotation
Chemicals (3 molecules)
1
1
2
1
3
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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