2PL2: Crystal Structure Of Ttc0263: A Thermophilic Tpr Protein In Thermus Thermophilus Hb27

Citation:
Abstract
The hypothetical protein TTC0263 of Thermus thermophilus HB27 is a thermophilic tetratricopeptide repeat (TPR)-containing protein. In the present study, the TPR region (residues 26-230) was resolved at 2.5 A with R-factors of R/Rfree = 23.6%/28.6%. TTC0263 consists of 11 helices that form five TPR units. Uniquely, it contains one atypical "extended" TPR (eTPR) unit. This comprises extended helical residues near the loop region of TTC0263, such that the helical length of eTPR is longer than that of the canonical TPR sequence. In addition, the hybrid TPR domain of TTC0263 possesses oligomer-forming characteristics. TPR domains are generally involved in forming multi-subunit complexes by interacting with each other or with other subunit proteins. The dynamic structure of TTC0263 described here goes some way to explaining how TPR domains mediate the formation of multi-subunit complexes.
PDB ID: 2PL2Download
MMDB ID: 62808
PDB Deposition Date: 2007/4/18
Updated in MMDB: 2017/10
Experimental Method:
x-ray diffraction
Resolution: 2.5  Å
Source Organism:
Similar Structures:
Biological Unit for 2PL2: dimeric; determined by author
Molecular Components in 2PL2
Label Count Molecule
Proteins (2 molecules)
2
Hypothetical Conserved Protein Ttc0263
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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