2PFH: Complex of Aldose Reductase with NADP+ and simaltaneously bound competetive inhibitors Fidarestat and IDD594. Concentration of Fidarestat in soaking solution is less than concentration of IDD594

PDB ID: 2PFHDownload
MMDB ID: 234990
PDB Deposition Date: 2007/4/5
Updated in MMDB: 2023/09
Experimental Method:
x-ray diffraction
Resolution: 0.85  Å
Source Organism:
Similar Structures:
Biological Unit for 2PFH: monomeric; determined by author
Molecular Components in 2PFH
Label Count Molecule
Protein (1 molecule)
1
Aldose Reductase
(Gene symbol: AKR1B1)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
1
CHLORIDE IONCHLORIDE ION
2
1
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATENADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
3
1
IDD594IDD594
4
1
(2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE(2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE
5
2
CITRIC ACIDCITRIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303