2PDZ: SOLUTION STRUCTURE OF THE SYNTROPHIN PDZ DOMAIN IN COMPLEX WITH THE PEPTIDE GVKESLV, NMR, 15 STRUCTURES

Citation:
Abstract
Syntrophins are modular proteins belonging to the dystrophin associated glycoprotein complex and are thought to be involved in the regulation of the muscular system. Screening of peptide libraries revealed selectivity of the synotrophin PDZ domain toward the motif R/K/Q-E-S/T-X-V-COO- found to be highly conserved in the alpha-subunit C-terminus of vertebrate voltage gated sodium channels (VGSCs). The solution structure of the domain in complex with the peptide G-V-K-E-S-L-V shows specific interactions between the conserved residues in the peptide and syntrophin-characteristic residues in the domain. We propose that syntrophins localize VGSCs to the dystrophin network through its PDZ domain.
PDB ID: 2PDZDownload
MMDB ID: 8953
PDB Deposition Date: 1997/12/10
Updated in MMDB: 2007/11
Experimental Method:
solution nmr
Source Organism:
synthetic construct
Similar Structures:
Molecular Components in 2PDZ
Label Count Molecule
Proteins (2 molecules)
1
Syntrophin(Gene symbol: Snta1)
Molecule annotation
1
Peptide Gvkeslv
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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