2OYV: Neurotensin in DPC micelles

Neurotensin (NT) is a 13-residue neuropeptide that exerts multiple biological functions in the central and peripheral nervous system. Little is known about the structure of this neuropeptide, and what is known only concerns its C-terminal part. We determined here for the first time the structure of the full-length NT in membrane-mimicking environments by means of classical proton-proton distance constraints derived from solution-state NMR spectroscopy. NT was found to have a structure at both its N and C termini, whereas the central region of NT remains highly flexible. In TFE and HFIP solutions, the NT C-terminus presents an extended slightly incurved structure, whereas in DPC it has a beta turn. The N-terminal region of NT possesses great adaptability and accessibility to the microenvironment in the three media studied. Altogether, our work demonstrates a structure of NT fully compatible with its NTR-bound state.
PDB ID: 2OYVDownload
MMDB ID: 46472
PDB Deposition Date: 2007/2/23
Updated in MMDB: 2007/10
Experimental Method:
solution nmr
Similar Structures:
Molecular Components in 2OYV
Label Count Molecule
Protein (1 molecule)
Molecule annotation
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