2OVY: Crystal Structure Of The Catalytic Domain Of Rat Phosphodiesterase 10a

Citation:
Abstract
A papaverine based pharmacophore model for PDE10A inhibition was generated via SBDD and used to design a library of 4-amino-6,7-dimethoxyquinazolines. From this library emerged an aryl ether pyrrolidyl 6,7-dimethoxyquinazoline series that became the focal point for additional modeling, X-ray, and synthetic efforts toward increasing PDE10A inhibitory potency and selectivity versus PDE3A/B. These efforts culminated in the discovery of 29, a potent and selective brain penetrable inhibitor of PDE10A.
PDB ID: 2OVYDownload
MMDB ID: 44814
PDB Deposition Date: 2007/2/15
Updated in MMDB: 2012/11
Experimental Method:
x-ray diffraction
Resolution: 1.8  Å
Source Organism:
Similar Structures:
Biological Unit for 2OVY: monomeric; determined by author
Molecular Components in 2OVY
Label Count Molecule
Protein (1 molecule)
1
Phosphodiesterase-10a(Gene symbol: Pde10a)
Molecule annotation
Chemicals (4 molecules)
1
1
2
1
3
1
4
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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