2OT8: Karyopherin Beta2/transportin-hnrnpm Nls Complex

Kapbeta2 (also called transportin) recognizes PY nuclear localization signal (NLS), a new class of NLS with a R/H/Kx((2-5))PY motif. Here we show that Kapbeta2 complexes containing hydrophobic and basic PY-NLSs, as classified by the composition of an additional N-terminal motif, converge in structure only at consensus motifs, which explains ligand diversity. On the basis of these data and complementary biochemical analyses, we designed a Kapbeta2-specific nuclear import inhibitor, M9M.
PDB ID: 2OT8Download
MMDB ID: 45956
PDB Deposition Date: 2007/2/7
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 3.1  Å
Source Organism:
Similar Structures:
Biological Unit for 2OT8: dimeric; determined by author and by software (PISA)
Molecular Components in 2OT8
Label Count Molecule
Proteins (2 molecules)
Transportin-1(Gene symbol: TNPO1)
Molecule annotation
Heterogeneous Nuclear Ribonucleoprotein M(Gene symbol: HNRNPM)
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB