2OQ1: Tandem SH2 Domains of Zap-70 With 19-mer Zeta1 Peptide

Citation:
Abstract
The crystal structure of the tandem SH2 domains of human ZAP-70 in complex with a peptide derived from the zeta-subunit of the T-cell receptor reveals an unanticipated interaction between the two domains. A coiled coil of alpha-helices connects the two SH2 domains, producing an interface that constitutes one of the two critical phosphotyrosine binding sites. These and other unique features provide the molecular basis for highly selective association of ZAP-70 with the T-cell receptor.
PDB ID: 2OQ1Download
MMDB ID: 44767
PDB Deposition Date: 2007/1/30
Updated in MMDB: 2012/11 
Experimental Method:
x-ray diffraction
Resolution: 1.9  Å
Source Organism:
synthetic construct
Similar Structures:
Biological Unit for 2OQ1: dimeric; determined by author and by software (PISA)
Molecular Components in 2OQ1
Label Count Molecule
Proteins (2 molecules)
1
Tyrosine-protein Kinase Zap-70
Molecule annotation
1
T-cell Surface Glycoprotein CD3 Zeta Chain
Molecule annotation
Chemical (1 molecule)
1
1
* Click molecule labels to explore molecular sequence information.

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