2OBJ: Crystal Structure of Human Pim-1 Kinase in Complex With Inhibitor

A novel series of highly potent substituted pyridone Pim-1 kinase inhibitors is described. Structural requirements for in vitro activity are outlined as well as a complex crystal structure with the most potent Pim-1 inhibitor reported (IC(50)=50 nM). A hydrogen bond matrix involving the Pim-1 inhibitor, two water molecules, and the catalytic core, together with a potential weak hydrogen bond between an aromatic hydrogen on the R(1) phenyl ring and a main-chain carbonyl of Pim-1, accounts for the overall potency of this inhibitor.
PDB ID: 2OBJDownload
MMDB ID: 44156
PDB Deposition Date: 2006/12/19
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 2.5  Å
Source Organism:
Similar Structures:
Biological Unit for 2OBJ: monomeric; determined by author
Molecular Components in 2OBJ
Label Count Molecule
Protein (1 molecule)
Proto-oncogene Serine/threonine-protein Kinase Pim-1(Gene symbol: PIM1)
Molecule annotation
Chemical (1 molecule)
* Click molecule labels to explore molecular sequence information.

Citing MMDB