2NTN: Crystal Structure Of Maba-c60v/g139a/s144l

The MabA protein from Mycobacterium tuberculosis is a validated drug target. Previous structural studies of this protein showed dynamic behaviour in the catalytic site and described motion between an open 'active' holo form (with NADP) and a closed 'inactive' apo form (without NADP). Here, a mutation (G139A) is reported that leads to complete protein inactivation and freezes the catalytic site into its closed form, even in the presence of the cofactor. This observation suggests a new way to develop anti-MabA drugs via protein stabilization of the 'inactive' form.
PDB ID: 2NTNDownload
MMDB ID: 43142
PDB Deposition Date: 2006/11/8
Updated in MMDB: 2006/12
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
Similar Structures:
Biological Unit for 2NTN: tetrameric; determined by author and by software (PISA,PQS)
Molecular Components in 2NTN
Label Count Molecule
Proteins (4 molecules)
3-oxoacyl-[acyl-carrier-protein] Reductase
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB