2NPA: The Crystal Structure Of The Human Pparaplpha Ligand Binding Domain In Complex With A A-hydroxyimino Phenylpropanoic Acid

Oxime ethers of alpha-acyl-beta-phenylpropanoic acids were prepared to apply as PPARalpha and gamma dual agonists. Among them, compound 11l proved to exhibit potent in vitro activities with EC(50) of 19 and 13nM in PPARalpha and gamma, respectively. It showed better glucose lowering effects than rosiglitazone 1 and ameliorated the lipid profile like plasma triglyceride in db/db mice model.
PDB ID: 2NPADownload
MMDB ID: 60106
PDB Deposition Date: 2006/10/26
Updated in MMDB: 2007/11
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
Homo sapiens
Similar Structures:
Biological Unit for 2NPA: dimeric; determined by author
Molecular Components in 2NPA
Label Count Molecule
Proteins (2 molecules)
Peroxisome Proliferator-activated Receptor Alpha(Gene symbol: PPARA)
Molecule annotation
Src- Peptide From Nuclear Receptor Coactivator 1
Molecule annotation
Chemical (1 molecule)
* Click molecule labels to explore molecular sequence information.

Citing MMDB