2N52: The solution structure of the kallikrein inhibitor SPINK6

Kallikrein-related peptidases (KLKs) are crucial for epidermal barrier function and are involved in the proteolytic regulation of the desquamation process. Elevated KLK levels were reported in atopic dermatitis. In skin, the proteolytic activity of KLKs is regulated by specific inhibitors of the serine protease inhibitor of Kazal-type (SPINK) family. SPINK6 was shown to be expressed in human stratum corneum and is able to inhibit several KLKs such as KLK4, -5, -12, -13 and -14. In order to understand the structural traits of the specific inhibition we solved the structure of SPINK6 in solution by NMR-spectroscopy and studied its interaction with KLKs. Thereby, beside the conserved binding mode, we identified an alternate binding mode which has so far not been observed for SPINK inhibitors.
PDB ID: 2N52Download
MMDB ID: 137383
PDB Deposition Date: 2015/7/6
Updated in MMDB: 2018/05
Experimental Method:
solution nmr
Source Organism:
Similar Structures:
Biological Unit for 2N52: monomeric; determined by author
Molecular Components in 2N52
Label Count Molecule
Protein (1 molecule)
Serine Protease Inhibitor Kazal-type 6(Gene symbol: SPINK6)
Molecule annotation
* Click molecule labels to explore molecular sequence information.

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