2MJX: Solution Nmr Structure Of A Mismatch Dna

Citation:
Abstract
Mutations in the genome are responsible for several fatal genetic disorders. The default DNA repair mechanism restores the malfunction of the gene caused by mutation to maintain functional regularity and sequential integrity of the cell. Here, we have elucidated the NMR structure and the dynamics of GC mismatched DNA (PDB code: 2MJX) and found that the mismatched DNA still retains the typical B-type helical form, but in the process introduces backbone distortion resulting from frame-shifted base pairs.
PDB ID: 2MJXDownload
MMDB ID: 117909
PDB Deposition Date: 2014/1/21
Updated in MMDB: 2015/09
Experimental Method:
solution nmr
Source Organism:
Biological Unit for 2MJX: dimeric; determined by author
Molecular Components in 2MJX
Label Count Molecule
Nucleotides(2 molecules)
1
DNA (5'-d(*gp*cp*gp*cp*ap*tp*gp*cp*tp*ap*cp*gp*cp*g)-3')
Molecule annotation
1
DNA (5'-d(*cp*gp*cp*gp*tp*ap*cp*gp*ap*tp*gp*cp*gp*c)-3')
Molecule annotation
* Click molecule labels to explore molecular sequence information.

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