2MFP: Solution structure of the circular g-domain analog from the wheat metallothionein Ec-1

Citation:
Abstract
The first cyclic analog of a metallothionein (MT) was prepared and analyzed by UV and (magnetic) circular dichroism spectroscopy, ESI-MS as well as NMR spectroscopy. Results reveal that the evaluated cyclic gamma-E(c)-1 domain of the wheat MT E(c)-1 retains its ability to coordinate two Zn(II) or Cd(II) ions and adopts a three-dimensional structure that is highly similar to the one of the linear wild-type form. However, the reduced flexibility of the protein backbone facilitates structure solution significantly and results in a certain stabilization of metal binding to the protein.
PDB ID: 2MFPDownload
MMDB ID: 115371
PDB Deposition Date: 2013/10/14
Updated in MMDB: 2013/12
Experimental Method:
solution nmr
Source Organism:
Similar Structures:
Biological Unit for 2MFP: monomeric; determined by author
Molecular Components in 2MFP
Label Count Molecule
Protein (1 molecule)
1
EC Protein I/ii(Gene symbol: LOC543479)
Molecule annotation
Chemicals (2 molecules)
1
2
* Click molecule labels to explore molecular sequence information.

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