2M7D: Trp-cage 16b P12W: a Hyperstable Miniprotein

The Trp-cage, at 20 residues in length, is generally acknowledged as the smallest fully protein-like folding motif. Linking the termini by a two-residue unit and excising one residue affords circularly permuted sequences that adopt the same structure. This represents the first successful circular permutation of any fold of less than 50-residue length. As was observed for the original topology, a hydrophobic staple near the chain termini is required for enhanced fold stability.
PDB ID: 2M7DDownload
MMDB ID: 116155
PDB Deposition Date: 2013/4/19
Updated in MMDB: 2013/12
Experimental Method:
solution nmr
Similar Structures:
Biological Unit for 2M7D: monomeric; determined by author
Molecular Components in 2M7D
Label Count Molecule
Protein (1 molecule)
Trp-cage Mini-protein
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB