2M5Y: Solution Structure of the C-terminal domain of RV0431

Mycobacterium tuberculosis (Mtb) restrains immune responses well enough to escape eradication but elicits enough immunopathology to ensure its transmission. Here we provide evidence that this host-pathogen relationship is regulated in part by a cytosolic, membrane-associated protein with a unique structural fold, encoded by the Mtb gene rv0431. The protein acts by regulating the quantity of Mtb-derived membrane vesicles bearing Toll-like receptor 2 ligands, including the lipoproteins LpqH and SodC. We propose that rv0431 be named "vesiculogenesis and immune response regulator."
PDB ID: 2M5YDownload
MMDB ID: 117762
PDB Deposition Date: 2013/3/13
Updated in MMDB: 2018/05
Experimental Method:
solution nmr
Source Organism:
Similar Structures:
Biological Unit for 2M5Y: monomeric; determined by author
Molecular Components in 2M5Y
Label Count Molecule
Protein (1 molecule)
Putative Tuberculin Related Peptide
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB