2KUB: Solution structure of the alpha subdomain of the major non-repeat unit of Fap1 fimbriae of Streptococcus parasanguis

The serine-rich repeat family of fimbriae play important roles in the pathogenesis of streptococci and staphylococci. Despite recent attention, their finer structural details and precise adhesion mechanisms have yet to be determined. Fap1 (Fimbriae-associated protein 1) is the major structural subunit of serine-rich repeat fimbriae from Streptococcus parasanguinis and plays an essential role in fimbrial biogenesis, adhesion, and the early stages of dental plaque formation. Combining multidisciplinary, high resolution structural studies with biological assays, we provide new structural insight into adhesion by Fap1. We propose a model in which the serine-rich repeats of Fap1 subunits form an extended structure that projects the N-terminal globular domains away from the bacterial surface for adhesion to the salivary pellicle. We also uncover a novel pH-dependent conformational change that modulates adhesion and likely plays a role in survival in acidic environments.
PDB ID: 2KUBDownload
MMDB ID: 83404
PDB Deposition Date: 2010/2/17
Updated in MMDB: 2010/07
Experimental Method:
solution nmr
Source Organism:
Similar Structures:
Molecular Components in 2KUB
Label Count Molecule
Protein (1 molecule)
Fimbriae-associated Protein Fap1
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB