2KQC: Second PBZ domain of human APLF protein

Addition of poly(ADP-ribose) (PAR) is an important post-translational modification in higher eukaryotes. Several DNA repair and checkpoint proteins possess specific PAR-binding zinc-finger (PBZ) modules critical for function. Here, we present solution structures of the two PBZ modules of aprataxin and PNK-like factor (APLF), revealing a novel type of zinc finger. By combining in vivo PAR-binding data with NMR interaction data using PAR fragments, we propose a structural basis for PBZ-PAR recognition.
PDB ID: 2KQCDownload
MMDB ID: 79372
PDB Deposition Date: 2009/11/4
Updated in MMDB: 2018/05
Experimental Method:
solution nmr
Source Organism:
Similar Structures:
Molecular Components in 2KQC
Label Count Molecule
Protein (1 molecule)
Aprataxin and Pnk-like Factor(Gene symbol: APLF)
Molecule annotation
Chemical (1 molecule)
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Citing MMDB