National Center for
2KI0: NMR Structure of a de novo designed beta alpha beta
Angew. Chem. Int. Ed. Engl. (2009) 48 p.3301-3303
A designer monomeric protein with a beta alpha beta fold--two parallel beta strands connected by an alpha helix (see structure)--was constructed solely from coded amino acids. The high thermal stability of the structure is due to a large extent to tryptophan-tryptophan interactions between the two beta strands.