2KDR: Solution structure of HCV NS4B(227-254)

Nonstructural protein 4B (NS4B) plays an essential role in the formation of the hepatitis C virus (HCV) replication complex. It is an integral membrane protein that has been only poorly characterized to date. It is believed to comprise a cytosolic N-terminal part, a central part harboring four transmembrane passages, and a cytosolic C-terminal part. Here, we describe an amphipathic alpha-helix at the C terminus of NS4B (amino acid residues 229 to 253) that mediates membrane association and is involved in the formation of a functional HCV replication complex.
PDB ID: 2KDRDownload
MMDB ID: 76957
PDB Deposition Date: 2009/1/15
Updated in MMDB: 2009/10
Experimental Method:
solution nmr
Similar Structures:
Molecular Components in 2KDR
Label Count Molecule
Protein (1 molecule)
Non-structural Protein 4B
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB