National Center for
2JH8: The Structure Of Bluetongue Virus Vp4 Reveals A Multifunctional Rna-capping Production-line
Nat. Struct. Mol. Biol. (2007) 14 p.449-451
Eukaryotic organisms cap the 5' ends of their messenger RNAs by a series of four chemical reactions. Some viruses achieve this using a single molecule; the crystal structure of such an enzyme from bluetongue virus reveals an elongated modular architecture that provides a scaffold for an assemblage of active sites, two contributed by a domain of novel structure.