2JGR: Crystal Structure Of Yegs In Complex With Adp

The human lipid kinase family controls cell proliferation, differentiation, and tumorigenesis and includes diacylglycerol kinases, sphingosine kinases, and ceramide kinases. YegS is an Escherichia coli protein with significant sequence homology to the catalytic domain of the human lipid kinases. We have solved the crystal structure of YegS and shown that it is a lipid kinase with phosphatidylglycerol kinase activity. The crystal structure reveals a two-domain protein with significant structural similarity to a family of NAD kinases. The active site is located in the interdomain cleft formed by four conserved sequence motifs. Surprisingly, the structure reveals a novel metal binding site composed of residues conserved in most lipid kinases.
PDB ID: 2JGRDownload
MMDB ID: 46323
PDB Deposition Date: 2007/2/14
Updated in MMDB: 2011/10
Experimental Method:
x-ray diffraction
Resolution: 2.65  Å
Source Organism:
Similar Structures:
Biological Unit for 2JGR: monomeric; determined by author and by software (PQS)
Molecular Components in 2JGR
Label Count Molecule
Protein (1 molecule)
Yegs(Gene symbol: yegS)
Molecule annotation
Chemical (1 molecule)
* Click molecule labels to explore molecular sequence information.

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