2JBY: A viral protein unexpectedly mimics the structure and function of pro- survival Bcl-2

Many viruses express antiapoptotic proteins to counter host defense mechanisms that would otherwise trigger the rapid clearance of infected cells. For example, adenoviruses and some gamma-herpesviruses express homologs of prosurvival Bcl-2 to subvert the host's apoptotic machinery. Myxoma virus, a double-stranded DNA virus of the pox family, harbors antiapoptotic M11L, its virulence factor. Analysis of its three-dimensional structure reveals that despite lacking any primary sequence similarity to Bcl-2, it adopts a virtually identical protein fold. This allows it to associate with BH3 domains, especially those of Bax and Bak. We found that M11L acts primarily by sequestering Bax and Bak, thereby blocking the killing action of these essential cell-death mediators. These findings expand the family of protein sequences that act like Bcl-2 to block apoptosis and support the conclusion that the prosurvival action of these proteins critically depends on their ability to bind and antagonize Bax and/or Bak.
PDB ID: 2JBYDownload
MMDB ID: 163269
PDB Deposition Date: 2006/12/14
Updated in MMDB: 2018/06
Experimental Method:
x-ray diffraction
Resolution: 2.41  Å
Source Organism:
Myxoma virus
Similar Structures:
Biological Unit for 2JBY: dimeric; determined by software (PISA)
Molecular Components in 2JBY
Label Count Molecule
Proteins (2 molecules)
M11l Protein
Molecule annotation
Bcl-2 Homologous Antagonist/killer 2
Molecule annotation
Chemical (1 molecule)
* Click molecule labels to explore molecular sequence information.

Citing MMDB