2J0A: Structure Of The Catalytic Domain Of Mouse Manic Fringe

Fringe proteins are beta1,3-N-acetylglucosaminyltransferases that modify Notch receptors, altering their ligand-binding specificity to regulate Notch signaling in development. We present the crystal structure of mouse Manic Fringe bound to UDP and manganese. The structure reveals amino acid residues involved in recognition of donor substrates and catalysis, and a putative binding pocket for acceptor substrates. Mutations of several invariant residues in this pocket impair Fringe activity in vivo.
PDB ID: 2J0ADownload
MMDB ID: 53623
PDB Deposition Date: 2006/8/1
Updated in MMDB: 2011/10
Experimental Method:
x-ray diffraction
Resolution: 1.8  Å
Source Organism:
Similar Structures:
Biological Unit for 2J0A: monomeric; determined by author and by software (PQS)
Molecular Components in 2J0A
Label Count Molecule
Protein (1 molecule)
Beta-1,3-n-acetylglucosaminyltransferase Manic Fringe(Gene symbol: Mfng)
Molecule annotation
Chemicals (2 molecules)
* Click molecule labels to explore molecular sequence information.

Citing MMDB