2IIT: Human dipeptidyl peptidase 4 in complex with a diazepan-2-one inhibitor

PDB ID: 2IITDownload
MMDB ID: 42954
PDB Deposition Date: 2006/9/28
Updated in MMDB: 2006/12
Experimental Method:
x-ray diffraction
Resolution: 2.35  Å
Source Organism:
Similar Structures:
Biological Unit for 2IIT: dimeric; determined by author and by software (PISA)
Molecular Components in 2IIT
Label Count Molecule
Proteins (2 molecules)
2
Dipeptidyl Peptidase 4 Soluble Form
(Gene symbol: DPP4)
Molecule annotation
Chemicals and Non-standard biopolymers (27 molecules)
1
22
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
2
2-acetamido-2-deoxy-alpha-D-glucopyranose2-acetamido-2-deoxy-alpha-D-glucopyranose
3
1
SODIUM IONSODIUM ION
4
2
(3R)-4-[(3R)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOYL]-3-(2,2,2-TRIFLUOROETHYL)-1,4-DIAZEPAN-2-ONE(3R)-4-[(3R)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOYL]-3-(2,2,2-TRIFLUOROETHYL)-1,4-DIAZEPAN-2-ONE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303