2I47: Crystal Structure Of Catalytic Domain Of Tace With Inhibitor

Citation:
Abstract
By focusing on the P1 portion of the piperidine beta-sulfone ligands we identified a motif that induces selectivity and resulted in a series of TACE inhibitors that demonstrated excellent in vitro potency against isolated TACE enzyme and excellent selectivity over MMPs 1, 2, 9, 13, and 14.
PDB ID: 2I47Download
MMDB ID: 42911
PDB Deposition Date: 2006/8/21
Updated in MMDB: 2006/12
Experimental Method:
x-ray diffraction
Resolution: 1.9  Å
Source Organism:
Similar Structures:
Biological Unit for 2I47: monomeric; determined by author
Molecular Components in 2I47
Label Count Molecule
Protein (1 molecule)
1
Adam 17(Gene symbol: ADAM17)
Molecule annotation
Chemicals (2 molecules)
1
1
2
1
* Click molecule labels to explore molecular sequence information.

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