2I1P: Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin

Megalin, an approx. 600 kDa transmembrane glycoprotein that acts as multi-ligand transporter, is a member of the low density lipoprotein receptor gene family. Several cysteine-rich repeats, each consisting of about 40 residues, are responsible for the multispecific binding of ligands. The solution structure of the twelfth cysteine-rich ligand-binding repeat with class A motif found in megalin features two short beta-strands and two helical turns, yielding the typical fold with a I-III, II-V and IV-VI disulfide bridge connectivity pattern and a calcium coordination site at the C-terminal end. The resulting differences in electrostatic surface potential compared to other ligand-binding modules of this gene family, however, may be responsible for the functional divergence.
PDB ID: 2I1PDownload
MMDB ID: 44489
PDB Deposition Date: 2006/8/14
Updated in MMDB: 2007/11
Experimental Method:
solution nmr
Source Organism:
Similar Structures:
Molecular Components in 2I1P
Label Count Molecule
Protein (1 molecule)
Low-density Lipoprotein Receptor-related Protein 2(Gene symbol: Lrp2)
Molecule annotation
Chemical (1 molecule)
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