2HCK: SRC FAMILY KINASE HCK-QUERCETIN COMPLEX

Citation:
Abstract
The crystal structure of the haematopoietic cell kinase Hck has been determined at 2.6/2.9 A resolution. Inhibition of enzymatic activity is a consequence of intramolecular interactions of the enzyme's Src-homology domains SH2 and SH3, with concomitant displacement of elements of the catalytic domain. The conformation of the active site has similarities with that of inactive cyclin-dependent protein kinases.
PDB ID: 2HCKDownload
MMDB ID: 6283
PDB Deposition Date: 1997/2/25
Updated in MMDB: 2012/11
Experimental Method:
x-ray diffraction
Resolution: 3  Å
Source Organism:
Similar Structures:
Biological Unit for 2HCK: dimeric; determined by author
Molecular Components in 2HCK
Label Count Molecule
Proteins (2 molecules)
2
Hematopoetic Cell Kinase HCK(Gene symbol: HCK)
Molecule annotation
Chemicals (4 molecules)
1
2
2
2
* Click molecule labels to explore molecular sequence information.

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