2HB1: Crystal Structure Of Ptp1b With Monocyclic Thiophene Inhibitor

A series of monocyclic thiophenes was designed and synthesized as PTP1B inhibitors. Guided by X-ray co-crystal structural information and computational modeling, rational design led to key interactions with Asp48 and improved inhibitory potency against PTP1B.
PDB ID: 2HB1Download
MMDB ID: 41019
PDB Deposition Date: 2006/6/13
Updated in MMDB: 2017/10
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 2HB1: monomeric; determined by author
Molecular Components in 2HB1
Label Count Molecule
Protein (1 molecule)
Tyrosine-protein Phosphatase Non-receptor Type 1(Gene symbol: PTPN1)
Molecule annotation
Chemical (1 molecule)
* Click molecule labels to explore molecular sequence information.

Citing MMDB