2H0P: NMR Structure of the Dengue-4 virus Envelope Protein Domain III

The disease dengue (DEN) is caused by four serologically related viruses termed DEN1, DEN2, DEN3 and DEN4. The structure of the ectodomain of the envelope protein has been determined previously for DEN2 and DEN3 viruses. Using NMR spectroscopic methods, we solved the solution structure of domain III (ED3), the receptor-binding domain, of the envelope protein of DEN4 virus, human strain 703-4. The structure shows that the nine amino acid changes in ED3 that separate the sylvatic and human DEN4 strains are surface exposed. Important structural differences between DEN4-rED3 and ED3 domains of DEN2, DEN3 and other flaviviruses are discussed.
PDB ID: 2H0PDownload
MMDB ID: 44999
PDB Deposition Date: 2006/5/15
Updated in MMDB: 2007/11
Experimental Method:
solution nmr
Source Organism:
Similar Structures:
Molecular Components in 2H0P
Label Count Molecule
Protein (1 molecule)
Envelope Glycoprotein
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB