2GVF: HCV NS3-4A protease domain complexed with a macrocyclic ketoamide inhibitor, SCH419021

PDB ID: 2GVFDownload
MMDB ID: 43836
PDB Deposition Date: 2006/5/2
Updated in MMDB: 2024/12
Experimental Method:
x-ray diffraction
Resolution: 2.5  Å
Source Organism:
Hepacivirus hominis▼
Similar Structures:
Biological Unit for 2GVF: dimeric; determined by author and by software (PISA)
Molecular Components in 2GVF
Label Count Molecule
Proteins (2 molecules)
1
Polyprotein
Molecule annotation
1
Polyprotein
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
ZINC IONZINC ION
2
1
(6R,8S,11S)-11-CYCLOHEXYL-N-(1-{[(2-{[(1S)-2-(DIMETHYLAMINO)-2-OXO-1-PHENYLETHYL]AMINO}-2-OXOETHYL)AMINO](OXO)ACETYL}BUTYL)-10,13-DIOXO-2,5-DIOXA-9,12-DIAZATRICYCLO[14.3.1.1~6,9~]HENICOSA-1(20),16,18-TRIENE-8-CARBOXAMIDE(6R,8S,11S)-11-CYCLOHEXYL-N-(1-{[(2-{[(1S)-2-(DIMETHYLAMINO)-2-OXO-1-PHENYLETHYL]AMINO}-2-OXOETHYL)AMINO](OXO)ACETYL}BUTYL)-10,13-DIOXO-2,5-DIOXA-9,12-DIAZATRICYCLO[14.3.1.1~6,9~]HENICOSA-1(20),16,18-TRIENE-8-CARBOXAMIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303