2GHM: Mutated Map Kinase P38 (mus Musculus) In Complex With Inhbitor Pg- 895449

A new class of tumor necrosis factor alpha (TNF-alpha) synthesis inhibitors based on an N-2,4-pyrimidine-N-phenyl-N'-phenyl urea scaffold is described. Many of these compounds showed low-nanomolar activity against lipopolysaccharide stimulated TNF-alpha production. X-ray co-crystallization studies with mutated p38alpha showed that these trisubstituted ureas interact with the ATP-binding pocket in a pseudo-bicyclic conformation brought about by the presence of an intramolecular hydrogen bonding interaction.
PDB ID: 2GHMDownload
MMDB ID: 38854
PDB Deposition Date: 2006/3/27
Updated in MMDB: 2017/10
Experimental Method:
x-ray diffraction
Resolution: 2.35  Å
Source Organism:
Similar Structures:
Biological Unit for 2GHM: monomeric; determined by author
Molecular Components in 2GHM
Label Count Molecule
Protein (1 molecule)
Mitogen-activated Protein Kinase 14(Gene symbol: Mapk14)
Molecule annotation
Chemical (1 molecule)
* Click molecule labels to explore molecular sequence information.

Citing MMDB