2GDO: 4-(aminoalkylamino)-3-benzimidazole-quinolinones As Potent Chk1 Inhibitors

Citation:
Abstract
CHK-1 is one of the key enzymes regulating checkpoints in cellular growth cycles. Novel 4-(amino-alkylamino)-3-benzimidazole-quinolinones were prepared and assayed for their ability to inhibit CHK-1. These compounds are potent cell permeable CHK-1 inhibitors and showed synergistic effect with a DNA-damaging agent, camptothecin.
PDB ID: 2GDODownload
MMDB ID: 44955
PDB Deposition Date: 2006/3/16
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 3  Å
Source Organism:
Similar Structures:
Biological Unit for 2GDO: monomeric; determined by author
Molecular Components in 2GDO
Label Count Molecule
Protein (1 molecule)
1
Serine/threonine-protein Kinase Chk1(Gene symbol: CHEK1)
Molecule annotation
Chemicals (3 molecules)
1
2
2
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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