National Center for
2GDO: 4-(aminoalkylamino)-3-benzimidazole-quinolinones As Potent Chk1 Inhibitors
Bioorg. Med. Chem. Lett. (2006) 16 p.3121-3124
CHK-1 is one of the key enzymes regulating checkpoints in cellular growth cycles. Novel 4-(amino-alkylamino)-3-benzimidazole-quinolinones were prepared and assayed for their ability to inhibit CHK-1. These compounds are potent cell permeable CHK-1 inhibitors and showed synergistic effect with a DNA-damaging agent, camptothecin.