2G36: Crystal Structure Of Tryptophanyl-trna Synthetase (ec (tryptophan-trna Ligase)(trprs) (tm0492) From Thermotoga Maritima At 2.50 A Resolution

A novel aminoacyl-tRNA synthetase that contains an iron-sulfur cluster in the tRNA anticodon-binding region and efficiently charges tRNA with tryptophan has been found in Thermotoga maritima. The crystal structure of TmTrpRS (tryptophanyl-tRNA synthetase; TrpRS; EC reveals an iron-sulfur [4Fe-4S] cluster bound to the tRNA anticodon-binding (TAB) domain and an L-tryptophan ligand in the active site. None of the other T. maritima aminoacyl-tRNA synthetases (AARSs) contain this [4Fe-4S] cluster-binding motif (C-x(2)(2)-C-x(6)-C-x(2)-C). It is speculated that the iron-sulfur cluster contributes to the stability of TmTrpRS and could play a role in the recognition of the anticodon.
PDB ID: 2G36Download
MMDB ID: 38377
PDB Deposition Date: 2006/2/17
Updated in MMDB: 2017/11
Experimental Method:
x-ray diffraction
Resolution: 2.5  Å
Source Organism:
Similar Structures:
Biological Unit for 2G36: dimeric; determined by author and by software (PISA,PQS)
Molecular Components in 2G36
Label Count Molecule
Proteins (2 molecules)
Tryptophanyl-trna Synthetase(Gene symbol: TM0492)
Molecule annotation
Chemicals (4 molecules)
* Click molecule labels to explore molecular sequence information.

Citing MMDB