2G01: Pyrazoloquinolones as Novel, Selective JNK1 inhibitors

Citation:
Abstract
A novel class of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as c-Jun-N-terminal kinase (JNK) inhibitors is described. These compounds were synthesized via the condensation of 2-nitrobenzaldehydes and hydroxypyrazoles. The structure-activity relationships (SAR) and kinase selectivity profile of the inhibitors are also discussed. Compound 16 was identified as a potent JNK inhibitor with good cellular potency.
PDB ID: 2G01Download
MMDB ID: 38771
PDB Deposition Date: 2006/2/10
Updated in MMDB: 2006/12
Experimental Method:
x-ray diffraction
Resolution: 3.5  Å
Source Organism:
Homo sapiens
Similar Structures:
Biological Unit for 2G01: dimeric; determined by author and by software (PISA)
Molecular Components in 2G01
Label Count Molecule
Proteins (2 molecules)
1
Mitogen-activated Protein Kinase 8(Gene symbol: MAPK8)
Molecule annotation
1
C-jun-amino-terminal Kinase-interacting Protein 1(Gene symbol: MAPK8IP1)
Molecule annotation
Chemicals (5 molecules)
1
4
2
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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