2FWW: Human Beta-tryptase Ii Complexed With 4-piperidinebutyrate To Make Acylenzyme

Improved peptide-based inhibitors of human beta tryptase were discovered using information gleaned from tripeptide library screening and structure-guided design methods, including fragment screening. Our efforts sought to improve this class of inhibitors by replacing the traditional Lys or Arg P1 element. The optimized compounds display low nanomolar potency against the mast cell target and several hundred-fold selectivity with respect to serine protease off targets. Thus, replacement of Lys/Arg at P1 in a peptide-like scaffold does not need to be accompanied by a loss in target affinity.
PDB ID: 2FWWDownload
MMDB ID: 37834
PDB Deposition Date: 2006/2/3
Updated in MMDB: 2017/10
Experimental Method:
x-ray diffraction
Resolution: 2.25  Å
Source Organism:
Similar Structures:
Biological Unit for 2FWW: tetrameric; determined by author and by software (PISA)
Molecular Components in 2FWW
Label Count Molecule
Proteins (4 molecules)
Tryptase Beta-2(Gene symbol: TPSAB1)
Molecule annotation
Chemicals (4 molecules)
* Click molecule labels to explore molecular sequence information.

Citing MMDB