2FOM: Dengue Virus NS2B/NS3 Protease

Citation:
Abstract
The replication of flaviviruses requires the correct processing of their polyprotein by the viral NS3 protease (NS3pro). Essential for the activation of NS3pro is a 47-residue region of NS2B. Here we report the crystal structures of a dengue NS2B-NS3pro complex and a West Nile virus NS2B-NS3pro complex with a substrate-based inhibitor. These structures identify key residues for NS3pro substrate recognition and clarify the mechanism of NS3pro activation.
PDB ID: 2FOMDownload
MMDB ID: 38298
PDB Deposition Date: 2006/1/13
Updated in MMDB: 2017/10
Experimental Method:
x-ray diffraction
Resolution: 1.5  Å
Source Organism:
Similar Structures:
Biological Unit for 2FOM: dimeric; determined by author and by software (PISA)
Molecular Components in 2FOM
Label Count Molecule
Proteins (2 molecules)
1
Polyprotein
Molecule annotation
1
Polyprotein
Molecule annotation
Chemicals (3 molecules)
1
1
2
2
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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