2FM2: HCV NS3-4A protease domain complexed with a ketoamide inhibitor, SCH446211

PDB ID: 2FM2Download
MMDB ID: 37777
PDB Deposition Date: 2006/1/6
Updated in MMDB: 2022/12
Experimental Method:
x-ray diffraction
Resolution: 2.7  Å
Source Organism:
Hepacivirus hominis▼
Similar Structures:
Biological Unit for 2FM2: tetrameric; determined by author and by software (PISA)
Molecular Components in 2FM2
Label Count Molecule
Proteins (4 molecules)
2
NS3 Protease/helicase
Molecule annotation
2
Ns4a Protein
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
2
ZINC IONZINC ION
2
1
BETA-MERCAPTOETHANOLBETA-MERCAPTOETHANOL
3
1
TERT-BUTYL [(1S)-1-({(1R,2S,5S)-2-[(3S,10S)-3-(CYCLOPROPYLMETHYL)-12-METHYL-4,5,8,11-TETRAOXO-10-PHENYL-2,6,9,12-TETRAAZATRIDECAN-1 -OYL]-6,6-DIMETHYL-3-AZABICYCLO[3.1.0]HEX-3-YL}CARBONYL)-2,2-DIMETHYLPROPYL]CARBAMATETERT-BUTYL [(1S)-1-({(1R,2S,5S)-2-[(3S,10S)-3-(CYCLOPROPYLMETHYL)-12-METHYL-4,5,8,11-TETRAOXO-10-PHENYL-2,6,9,12-TETRAAZATRIDECAN-1 -OYL]-6,6-DIMETHYL-3-AZABICYCLO[3.1.0]HEX-3-YL}CARBONYL)-2,2-DIMETHYLPROPYL]CARBAMATE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303