2FK9: Human Protein Kinase C, Eta

Protein kinase C eta (PKCeta) is one of several PKC isoforms found in humans. It is a novel PKC isoform in that it is activated by diacylglycerol and anionic phospholipids but not calcium. The crystal structure of the PKCeta-C2 domain, which is thought to mediate anionic phospholipid sensing in the protein, was determined at 1.75 A resolution. The structure is similar to that of the PKC epsilon C2 domain but with significant variations at the putative lipid-binding site. Two serine residues within PKC eta were identified in vitro as potential autophosphorylation sites. In the unphosphorylated structure both serines line the putative lipid-binding site and may therefore play a role in the lipid-regulation of the kinase.
PDB ID: 2FK9Download
MMDB ID: 37391
PDB Deposition Date: 2006/1/4
Updated in MMDB: 2012/11
Experimental Method:
x-ray diffraction
Resolution: 1.75  Å
Source Organism:
Similar Structures:
Biological Unit for 2FK9: monomeric; determined by author
Molecular Components in 2FK9
Label Count Molecule
Protein (1 molecule)
Protein Kinase C, ETA Type(Gene symbol: PRKCH)
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB