National Center for
2FJI: Crystal Structure Of The C-terminal Domain Of The Exocyst Subunit Sec6p
Nat. Struct. Mol. Biol. (2006) 13 p.555-556
The exocyst is a conserved protein complex essential for trafficking secretory vesicles to the plasma membrane. The structure of the C-terminal domain of the exocyst subunit Sec6p reveals multiple helical bundles, which are structurally and topologically similar to Exo70p and the C-terminal domains of Exo84p and Sec15, despite <10% sequence identity. The helical bundles appear to be evolutionarily related molecular scaffolds that have diverged to create functionally distinct exocyst proteins.